Definium's LSD-based depression pill delivers strong late-stage results

How do you do a double-blind with a drug that perceptibly changes your state of mind?

RugnirViking 17 hours ago | parent | next [-]

I guess you do it anyway? the change in the state of mind is thought to be at least in part the mechanism of action, no? so if thats what makes it work, its good to test it against a non hallucinogen

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fragmede 17 hours ago | parent | prev [-]

You can't, and it's a real problem for some people. Other people realize that, like testing the efficacy of parachutes by throwing two people off an airplane, one without a parachute; other people realize the double blind standard can't be applied but that the results aren't woo mystical astrology unfounded conclusions despite that.

	▲	thepotatodude 15 hours ago \| parent [-]
		academia is struggling to realize this

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amanaplanacanal a day ago | parent | prev | next [-]

What is their dosing schedule? It says single dose, but how much are they giving?

	▲	tclover 21 hours ago \| parent [-]
		It’s a single 100-microgram dose. It temporarily dampens the Default Mode Network (DMN), creating a "reset window" for the brain to rebuild its pathways. https://ir.definiumtx.com/news-events/press-releases/detail/...

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andsoitis a day ago | parent | prev | next [-]

pretty exciting if this passes FDA approval. it's getting close.

	▲	Acrobatic_Road a day ago \| parent [-]
		I'm going to skip the line on this one.

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znpy 18 hours ago | parent | prev | next [-]

> Definium Therapeutics tab said a single dose of its LSD-based experimental pill significantly reduced symptoms of major depression

Reminds me of Soma from “brave new world” by aldus huxley.

We’re only missing a way to generate some pre-conditioned humans and we’re pretty much done (birthrates are already falling anyway, no need for malthusian practices).

	▲	evanjrowley 11 hours ago \| parent \| next [-]
		Aldus Huxley was a proponent of LSD[0]. The Soma in his Brave New World is not meant to represent it. [0] https://daily.jstor.org/when-aldous-huxley-dropped-acid/
	▲	fragmede 17 hours ago \| parent \| prev [-]
		Do other antidepressants, of which there are many, remind you of Soma as well?

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qsxfthnkp2322 21 hours ago | parent | prev [-]

What happens if I take 10?

Oh wait. That layoff caused my health insurance to quit working.

Oh well, can’t have any fun these days.