Do VMS not work for this?

There's one use case where VMs don't work, real time media processing. Mac is the preferred platform for this kind of think by most users but I use one application which is windows exclusive: rocksmith. It's theoretically possible to get something that's only marginally worse than the native experience, but I've never seen it done. Even if I could do it, I don't know if I could accept how the app behaves in practice.