| ▲ | Making Claude a Chemist(anthropic.com) |
| 51 points by gmays 9 hours ago | 48 comments |
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| ▲ | andai 4 hours ago | parent | next [-] |
| If they succeed here, won't they have to gate access to this feature, too? For the same reasons as, "if I so much as mention mitochondria, it downgrades me to Opus." Step 1. Make it so Claude can do anything — the whole point of AGI Step 2. Wait, if the user can do Anything, that would be Very Bad! Step 3. Err on the safe side with blanket bans of entire fields The latter actually seems to me a sensible reaction to e.g. the compartmentalization used in the large scale cyber attack using Claude last year. Where they were able to do Bad Thing by dividing it into many, many Small, Seemingly Harmless Things. Gated access sounds bad (and I agree it sounds bad!) but it might actually be the only sensible response to such a set of conditions. I'm not sure though. -- I saw some studies recently which showed LLMs provide much more detailed information to expert users. So we can distinguish between competence and incompetence based on use of language, and that is a reasonable metric for harm reduction. But I don't think we can reliably detect "user has harmful intentions", at least not at a sufficient level of sophistication of the attacker. |
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| ▲ | NewsaHackO 4 hours ago | parent | next [-] | | I think one time I asked opus about copyfail when it just came out and it did treat me like some sort of criminal, but are there really people that run into this on a regular basis other than cybersecurity experts (which cannot be a big enough group to generate all of this criticism)? | | |
| ▲ | dmd 28 minutes ago | parent [-] | | I asked it to clip a video onto segments based on location of spoken words (using separately done audio transcription) and it flagged that as cyber. |
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| ▲ | MiracleRabbit 4 hours ago | parent | prev | next [-] | | I just wait until a Opensource model inhaled all the chemistry books and papers. Lol. They are following closely and the best offer 80-90% of the performance and come with a very small fraction of the costs. | | |
| ▲ | echelon_musk 3 hours ago | parent [-] | | Why wouldn't the US gov. outlaw the open source models? | | |
| ▲ | squidbeak 27 minutes ago | parent | next [-] | | Without international treaty and regulation restricting frontier capabilities globally, any attempt to outlaw open source models will only be as effective as King Canute ordering the tide to turn. Unless the USA fancies bombing those who refuse. | |
| ▲ | MiracleRabbit 3 hours ago | parent | prev | next [-] | | Streisand effect Deepseek.v4.Pro.RePacked.LLMBoyz.part1.zstd | | | |
| ▲ | UltraSane 2 hours ago | parent | prev [-] | | Much harder to ban if they can run locally |
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| ▲ | UltraSane 2 hours ago | parent | prev [-] | | Fable wouldn't even explain what an amino acid is. |
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| ▲ | gopalv 6 hours ago | parent | prev | next [-] |
| The non-professional side of Organic Chemistry is one place where I think AI would really shine. Feels complex like solving a Rubik's cube to write down synthesis steps but it is all a sequence of memorized tricks. Do Cannizaro if you want this, Bergmann to do that. But the synthesis plan is only 10% of the actual work. The gap between writing down the synthesis step and actually doing it is also extremely large. Even if you get the right molecule, it might be the wrong way around or just clump up into a useless mess. The Ritonavir episode of Veritasium is a great example of how all chemistry on paper is a mere shadow of what actually happens in real life. |
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| ▲ | ElFitz 4 hours ago | parent | next [-] | | > Feels complex like solving a Rubik's cube to write down synthesis steps but it is all a sequence of memorized tricks. Do Cannizaro if you want this, Bergmann to do that. I remember two years ago, when I actually got into using graph data structures, wondering if maybe the "space" of available reactions for any given starter and target molecules could be mapped as a graph, with intermediates as nodes and reactions as weighted directed edges, so synthesis becomes pathfinding through chemical space. Turns out, it’s a thing! [^0] Edit: Makes you wonder how much interesting stuff is sitting in plain sight, waiting for someone with the right cross-domain awareness / knowledge / whatever to notice it. [0]: https://pmc.ncbi.nlm.nih.gov/articles/PMC9574932/ | | |
| ▲ | gilleain 3 hours ago | parent [-] | | There is a lot of graph theory in Chemistry - modelling chemicals as (vertex/edge coloured) graphs, reaction networks, etc. Of course some molecules (eg aromatic systems, like ferrocene) are not naturally representable as graphs. I wonder if it is the same with synthesis - are there reactions hard to model as a graph (or petri net or whatever). One simple example I know is that you have to be careful with including a node for 'water' as it gets connected to everything else! Or at least in biochemistry it does. |
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| ▲ | jgilias 6 hours ago | parent | prev | next [-] | | > Even if you get the right molecule, it might be the wrong way around or just clump up into a useless mess. Sounds a lot like vibe coding lol | | |
| ▲ | fakedang 5 hours ago | parent | next [-] | | Modern biochemistry (so far) IS vibe coding lol. You mostly have vibes on how the chemistry should work, based on (very strong) natural evidence coupled with theoretical development and lab studies. Then you mix and match, goading bacteria and praying that they produce what you want in good measure. Then you take their secretions and run chromatography studies on them to check if that's what you actually want, or whether it's just some random bullshit. If it's the latter, you have to toss that out and start all over again. | |
| ▲ | moffkalast 5 hours ago | parent | prev [-] | | At least vibe coding can only explode in your face metaphorically. | | |
| ▲ | b112 3 hours ago | parent [-] | | Until vibe code is used for weapons system, or explosive manufacturers, or.. or... The world today is coding. |
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| ▲ | reinitctxoffset 5 hours ago | parent | prev [-] | | Organic chemistry seems like a discipline better done by chemists than forward deployed staff with their payoff function sharply truncated at an IPO which at this point may or may not happen on schedule. |
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| ▲ | matheusmoreira 6 hours ago | parent | prev | next [-] |
| What good is it if you can't use it? Or worse, if you can but it silently sabotages you? |
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| ▲ | yorwba 6 hours ago | parent [-] | | > We measured three Claude models (Opus 4.7, Opus 4.6, Sonnet 4.6) You can use those and they probably won't intentionally sabotage you. | | |
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| ▲ | sandermvanvliet 2 hours ago | parent | prev | next [-] |
| Waiting for Claude to end up on Derek Lowe’s list of things he won’t work with |
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| ▲ | xvilka 4 hours ago | parent | prev | next [-] |
| Combine it with automated lab like this[1][2][3][4][5] (and many others) and it will iterate much quicker. Some already do but at a smaller scale, AFAIK. [1] https://www.ginkgo.bio/autonomous-lab [2] https://www.emeraldcloudlab.com/ [3] https://www.kebotix.com/ [4] https://www.chemify.io/ [5] https://arxiv.org/abs/2507.01485 |
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| ▲ | sudhirkhanger 2 hours ago | parent | prev | next [-] |
| Are there organizations or individuals using AI to solve world problems if they are so powerful as these companies are saying? |
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| ▲ | anentropic 4 hours ago | parent | prev | next [-] |
| I guess the future is one where every idiot has access to a genius servant, and all that implies |
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| ▲ | thefounder 6 hours ago | parent | prev | next [-] |
| Let’s ban this before it gets too powerful ! |
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| ▲ | simulator5g 6 hours ago | parent | next [-] | | I don't think it should be outright banned, automated intelligence is like a gun, hammer, knife, nuclear warhead, etc. | | |
| ▲ | pkal 5 hours ago | parent | next [-] | | I see that intelligence itself is a tool, but that doesn't mean I want an automated gun, automated hammer, automated nuclear warhead, etc. | | |
| ▲ | fakedang 5 hours ago | parent [-] | | You may not want them, but the NRA certainly wants that you want them. | | |
| ▲ | ben_w 5 hours ago | parent [-] | | In the future perhaps it will mean "Neural Rifle Automaton" |
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| ▲ | tearwear 6 hours ago | parent | prev | next [-] | | not really, though. you don't see automated intelligence in the hands of junkies et al. ... and you don't see it coming, either ... | | |
| ▲ | simulator5g 5 hours ago | parent [-] | | Junkies et al can log into chatgpt right now and use it to create a phishing email to steal drug money from your Grandma. Many people saw this coming. | | |
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| ▲ | xaxfixho 5 hours ago | parent | prev [-] | | [dead] |
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| ▲ | ed_mercer 3 hours ago | parent | prev | next [-] | | I wonder if every future announcement will be met with this criticism. Like, what's the point if they'll ban it in a few days. | |
| ▲ | UltraSane 2 hours ago | parent | prev [-] | | I don't really want the average LLM being able to tell anyone exactly how to syntheize lethal nerve agents. | | |
| ▲ | bouncycastle an hour ago | parent | next [-] | | you can already get that information by reading books in the library. The biggest barrier is not information, it's the ability to secure enough of the materials and equipment. For example, information for how to make a nuclear weapon is already there in the library. However, mining enough yellow cake and then purifying it is an industrial scale operation, out of reach unless you are a nation state, and have good mountain tunnels, etc. To a lesser extent, this is also true for producing chemical weapons. The theory is there, but actual production extremely out of reach. No LLM can help you there. (You can verify by reading up on Aum Shinrikyo to get an idea of the staggering scale required) | | |
| ▲ | dmd 23 minutes ago | parent | next [-] | | Sure, information on all sorts of things is in “the library”. But (a) most people in the world don’t have access to a decent library (if you’re on HN you’re statistically much more likely to), (b) most people have no idea how to use one (same), and most importantly (c) AI will distill the knowledge from ten books you might need to read into step by step simple instructions if you ask. | |
| ▲ | defrost an hour ago | parent | prev [-] | | > mining enough yellow cake and then purifying it is an industrial scale operation, out of reach unless you are a nation state or a transnational (or even national scale) energy and or minerals company. Might be hard to slip past the shareholders, but dark projects have flown under the annual reports of several large players. |
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| ▲ | an hour ago | parent | prev [-] | | [deleted] |
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| ▲ | smj-edison 5 hours ago | parent | prev | next [-] |
| I feel like chemistry is one thing that current models will struggle with for the next while, because it's inherently 3D. In the micro world, shape = function. Maybe enough textual patterns will let it under chemistry, but like how do you describe a hydrogen shift without showing how it moves positions and rebalances bonds? |
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| ▲ | snovv_crash 9 minutes ago | parent | next [-] | | I work a lot with the geometry side of computer vision (camera calibration, 3d reconstruction etc.) and LLMs have been really bad in this space. They throw stuff at the problem until a minor improvement is made by over fitting on a testset, then gaslight that this is the best thing possible. Then I go do something like working with raster-based data, or some JavaScript based visualization, and it goes super smoothly. | |
| ▲ | FailMore 3 hours ago | parent | prev | next [-] | | I think this is a very interesting concept/question. I feel like programming is more about shapes than anything else… but they seem to have mastered that fairly easily… but I totally get your point! | |
| ▲ | johncole 3 hours ago | parent | prev [-] | | Agree here, chem may be more complex than language, and not as definable as language. I think this is the realm that physical ai will overlap with. |
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| ▲ | jgilias 6 hours ago | parent | prev | next [-] |
| inb4 someone calls Bessent to explain how this can be used in fentanyl production. |
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| ▲ | exitnode 3 hours ago | parent | prev | next [-] |
| I vote for "Claude Pinkman" as a name |
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| ▲ | andrewstuart 2 hours ago | parent | prev | next [-] |
| “I can’t tell you that, you might hurt yourself.” |
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| ▲ | hansmayer 3 hours ago | parent | prev [-] |
| [dead] |