I'll note that speedrunners absolutely buffer mid-pipeline in Factorio, and not just for hand-crafting purpouses. Sometimes you're waiting for R&D, sometimes you're just running half the machines for twice as long, giving you the same output while saving on build costs. The actual bottlenecks are constantly shifting. "I'm not speedrunning!" you might say, but every regular game could've started as a speedrun that could've gotten you to where you are faster.

Understanding the tendency of mid-pipeline buffers to hide problems is useful, but scorning them entirely is also suboptimal.