Not all synthetics are dangerous, many are. Many are banned, with the list growing each year: https://www.npic.orst.edu/reg/restricted.html

Why were they allowed in the first place, if "research" was enough? Science is not definitive, and what we believe to be an approximation of the truth today way be discovered to be totally wrong tomorrow. You are confusing science and religion.

Would you defend, for instance, that DDT and other organochlorine poisons are safe? They were the darling of scientists and agrobiz companies for a long time, until we discovered well that they were dangerous.

Of course, if we find a strict equivalent to a biopesticide that happens to be synthetical, it would be a good substitute. But most synthetic pesticides are not like this, unfortunately.

And what you say about the lack of studies regarding organic farming is a plain lie, it takes 30 seconds on google scholar to find it:

- Farmers in organic farms are less exposed to health effects of synthetic pesticides: https://www.sciencedirect.com/science/article/abs/pii/S03784...

- Organic farming improve soils and yields: https://www.sciencedirect.com/science/article/pii/S1658077X2...

- Review on organic food quality and health effects: https://link.springer.com/content/pdf/10.1186/s12940-017-031...