> Cell sizes are not fixed, however, even within a single species. Cells often swell as they increase their production of proteins and metabolites in preparation for division. This is in line with biology’s only rule: namely, there are exceptions to every rule!

> Case in point: a giant bacterium called Thiomargarita magnifica can extend about one centimeter in length, so large that it can be seen by the naked eye. It does so by breaking the surface area-to-volume rule, filling between 65–80 percent of its internal volume with an empty vacuole. In other words, it pushes most of its molecules to the cell periphery, thus shortening diffusion distances.

There is also a captioned image of bubble algae in the post.

Interesting topology. How empty is the vacuole?

> This is in line with biology’s only rule: namely, there are exceptions to every rule!

Nice paradox