I had to start using noTunes years ago because whenever I accidentally touched or removed my (Sony / non-Apple) bluetooth headphones, iTunes/Music would pop up without fail. Apparently they sent a "play" button press, so the application would pop up. Because it's a system application, you cannot delete it, there's no way to override the key, there's no way to disable it. So noTunes has been running for 7 years straight on my Mac.