I think that it's pretty difficult to do an empirical study, here. The culture makes a big difference. I feel as if Americans can do remote "better" than other cultures, where constant human interaction is common. We already have a fairly isolated culture. That's not necessarily a good thing, though. It could be, that the increased isolation of remote is a "tipping point" kind of thing.

In the US, it already happens to retired people; especially men (my age). I know, for myself, that I'm fortunate as hell to participate in an organization that forces me to interact, fairly intimately, with others, on an almost daily basis.

All that said, there's also strong interests, that want the results to skew one way or another, and we already know that most research needs to be looked at, with a jaundiced eye (not new -people have been throwing research for decades).