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seethishat 2 hours ago

The newer synthetic nicotine pouches (Zyn, On, Velo) are everywhere in the USA and are being used by kids as young as 13. They are ruining the gut health of an entire generation of kids.

Edit: Both boys and girls are dependent on these things now and they seem socially acceptable (no smoke, no spit, just swallow the chemical nicotine). Get ready for a huge wave of GI problems due to this.

ipsento606 an hour ago | parent | next [-]

Source for the claim that nicotine use "ruins" gut health?

My understanding is that the relationship between nicotine and gut health (indeed, overall health) is much more complex and nuanced than that. I know that nicotine has a positive effect on ulcerative colitis symptoms for many sufferers.

https://pmc.ncbi.nlm.nih.gov/articles/PMC8895249/#s4

A quote:

Of all the diseases summarized here concerning systemic inflammation, especially in sepsis and endotoxemia, nicotine exerted the most pharmaceutical effect and significantly improved the survival. Next, nicotine is also a potential candidate for treating ulcerative colitis, rheumatoid arthritis, osteoarthritis, multiple sclerosis, and myocarditis; the in vivo data provided a much better foundation. For local inflammation, the nicotine administration route may be more important to avoid its accumulation in other healthy organs—for example, the effect of nicotine on arthritis will be more pronounced when nicotine is directly injected into the focus of infection. Perhaps that is why, in the early years, tobacco was used to treat enteritis as enemas (4). It is evident that nicotine has a significant pro-inflammatory effect on periodontitis. However, the latest research also found that nicotine positively affects periodontitis at a lower dosage. In this regard, we consider that the effect of nicotine on periodontitis is mainly due to the influence of inevitable and original oral microbes. At present, most studies focus on the cellular level, and in vivo studies may be limited due to the difficulty of model construction. Therefore, we recommend that individuals with poor oral hygiene avoid excessive direct exposure to nicotine for oral diseases.

wossab 2 hours ago | parent | prev | next [-]

And teeth. This stuff will do nasty things to your gums. And receded gums never recover.

Forgeties79 2 hours ago | parent [-]

Unless you do an incredibly painful graft right? I have a buddy who had to do that in college and man it seemed incredibly unpleasant. They harvested the skin from the roof of his mouth IIRC

Edit: yikes sounds like it gets worse and might not even work

loloquwowndueo an hour ago | parent | next [-]

My dentist has been peddling this procedure to me for years. It sounds incredibly invasive and painful and they don’t even promise it’ll cover 100% of the recession, nor that it won’t recede again unless one goes for an even more invasive jaw realignment which involves, I shit you not, intentionally fracturing the palate bone to make more space to align the teeth.

That was the “let me stop you right there” moment.

(Not even going into how much these horrendous procedures cost!)

port11 an hour ago | parent | next [-]

What you’re describing sounds terrible in isolation, but usually these measures are only done if truly needed — at least in Europe?

I passed on the jaw realignment surgery, knowing that the consequences are more bone wear over time and that I’ll never fully recover usage on the left side of my mouth.

None of the dentists/orthos/surgeons involved said I *had* to do it, there is a trade off. Breaking your jaw might weaken it down the line, but bone wear along the tooth line isn’t great either. It’s a tough call.

Grafting is another thing I’ve been postponing, but now the proximity to my roots is getting painful as sensitivity piles up.

Again: this is all optional and full of trade-offs. Sibling comment suggesting you change dentists is not doing a fair assessment of the situation.

People with bad teeth, on average, die younger and have worse diets.

loloquwowndueo 12 minutes ago | parent [-]

> usually these measures are only done if truly needed — at least in Europe?

I’m not in Europe :)

Nah my dude, my dentist peddles all sorts of ridiculous unnecessary treatments. Invisalign? I’m 50, I don’t give a shit about how my teeth look, just want them not to fall off all at once. Invisalign is a subscription for your teeth. No thanks.

I stay with this dentist because they are friendly, technically competent and a 5-minute walk from home. Literally the only downside is the FUD to get me to go for those treatments but it’s just steeling myself to say “no thanks” every 6 months.

ptaffs an hour ago | parent | prev [-]

i had this suggested to me by a locum dentist, and i agree. This is totally off topic and going further so but if you didn't already, you should change your dentist.

loloquwowndueo 10 minutes ago | parent [-]

Thanks but I won’t. My dentist is fine otherwise, I can say “no”, they’re ok with me saying “no”.

We get along great and I find that’s both hard to find and super important - no better way of putting off dentist visits than having a dentist you dread seeing every 6 months.

data-ottawa an hour ago | parent | prev [-]

I had to do a graft and it wasn’t especially painful. I got painkillers but only used them on the first day.

The recovery period sucked, I needed antibiotics and couldn’t eat anything solid for two weeks.

If you can behaviourally prevent needing gum grafts you should.

embedding-shape an hour ago | parent | prev [-]

Is your problem with them that they're synthetic, or that it's nicotine? Pouched tobacco like that been used for decades in some places in the world, or even without pouches, just making your own ball and sticking the tobacco under your lip. I'm not sure these countries have a higher rate of GI/gut problems than other places, which kind of would invalidate your entire argument here.

seethishat an hour ago | parent | next [-]

My problem is it is an experiment (synthetic nicotine that is socially acceptable) and kids are addicted to it. It's like candy. No one knows or complains because the users are not generating smoke, vapor or spit. They just swallow the synthetic nicotine.

Yes, people have used tobacco products for a long time. However, they have not sucked on them like candy and swallowed the contents 16 hours a day. They spit, exhaled, etc. Chewing tobacco and snuff are not acceptable and they ruin your teeth/gums. Smoking is not acceptable and it ruins your lungs/breathing ability. This stuff is socially OK, because no one can tell you are using it (no spit or smoke).

Check out all the reports of GI issues on reddit (QuittingZyn). This stuff causes all sorts of GI issues from the top of the stomach to the bottom of the bowel.

mapt 40 minutes ago | parent | next [-]

Spitting was necessary because swallowing tobacco represents an immediate, acute food poisoning issue due to the other chemicals present. It's also all sorts of cancerous, including to the mouth, also due to those other chemicals.

We developed, in Snus, an apparently cancer-free chewing tobacco. We developed, in Zyn, a cancer-free, hygienic chewing tobacco with fewer GI issues. We developed, in e-cigarettes / vapes, a cancer-free, COPD-free, carbon monoxide free cigarette.

These should be regarded as public health miracles even if there remain some symptoms of partaking. If 80% of the population is addicted to Zyn or vapes but there are no smokers, you get far better health outcomes than a situation where 20% of the population are smoking and 5% are chewing.

embedding-shape an hour ago | parent | prev | next [-]

> However, they have not sucked on them like candy and swallowed the contents 16 hours a day.

Again, maybe not where you are, but there are definitively countries where both adults and children have tabacco under their lip for most of their waking hours, with no spitting or exhalation involved, as they're inside school/offices, can't really just spit there, even the non-synthetic stuff, as that's relatively new.

Zyn is specifically synthetic isn't it? You still seem to be mostly focused on synthetic nicotine, but the same behavior been observed for many, many decades with non-synthetics too.

pessimizer 14 minutes ago | parent | prev | next [-]

> However, they have not sucked on them like candy and swallowed the contents 16 hours a day.

Swedish Snus has been around a long time, isn't linked to cancer at all, and has no bad effect on your teeth and gums. Snus is actually associated with vast drops in cancer rates, because it usually replaces smoking. Snus is also no-spit - I think the difference between it and chewing tobaccos is that they are roasted and that snus is steamed. Makes a huge difference healthwise.

I don't have anything to say about the synthetic stuff, I'm not familiar. It's a bizarre industry that cropped up during a period where snus was trying to get into the market and the tobacco companies were trying to keep them out.

Somehow, cigarette companies lobbied to get snus caught up in cigarette taxes, even without the actual health risk. They were only even required to put the weakest possible warning on the package, because the health effects of snus have been well-studied and they're not associated with anything serious, except for nicotine addiction itself (which makes it a good substitute for smoking.)

The big US cigarette companies marketed a few horrible "snus" lines, with the marketing and goal that they would be a replacement product for when a smoker couldn't take a smoke break, and they were weak. I assume these synthetic lines developed to avoid taxes in some way by pretending to be a sort of medical product rather than a tobacco product, like a nicotine gum.

Snus is actually a better Nicorette, I suspected that the nicotene replacement industry had something to do with the sabotage of snus. Snus is cheap, free of health consequences, and doesn't lead you to associate something as addictive as chewing with nicotine consumption. Snus just quietly sits behind your lip, the minis are undetectable by the people you're interacting with, and they smell nice so they don't ruin your breath. Why would you choose a more expensive synthetic alternative?

irishcoffee an hour ago | parent | prev [-]

Zyn has been around for well over 10 years. We would be seeing this gut thing you talk of by now I would think.

42 minutes ago | parent [-]
[deleted]
DanielHB an hour ago | parent | prev | next [-]

Snus (tobacco pouches you put under your gums) is super popular in Sweden:

https://en.wikipedia.org/wiki/Snus

It is basically the same thing but not synthetic. Supposedly nicotin pouches are not as harmful because they do not have tobacco leaves.

I am a bit ambivalent about it, on one hand people don't smoke as much because snus which means I don't get as much second hand smoke.

On the other hand it is WAY easier for kids to get started on it as they don't need to hide it after they put it in their mouths. I know a few people who are heavily addicted to it (one even keeps one in when he is sleeping) and they all started in their early teens.

embedding-shape an hour ago | parent [-]

Exactly what I'm talking about, just didn't want to name it by name as people have a lot of preconceived notions about it that pops up as soon as you say "snus", for some reason.

DanielHB 16 minutes ago | parent [-]

I never heard about it causing GI problems, but snus definitely causes major teeth and gum problems. The guy I mentioned had his gums receded completely, he once showed it to me. It was very bizarre.

Also see this other comment on this thread about this issue:

https://news.ycombinator.com/item?id=48411778

throwaway173738 an hour ago | parent | prev | next [-]

You customarily spit out that saliva that’s been in contact with your dip. Swallowing it is way worse for you. When I framed houses the guys that chewed would leave a little trail of brown spots everywhere.

embedding-shape an hour ago | parent [-]

> You customarily spit out that saliva that’s been in contact with your dip

I don't think this is necessarily true everywhere/for everyone, it's really not common in Sweden to walk around spitting just because you have tobacco under your lip, as people sit in offices and stuff with this in their mouth, can't really go around a spit indoors.

gwbas1c an hour ago | parent | prev [-]

The problems with chewing tobacco are well-known.

BTW, colon cancer is rising among men in their 40s, and there is no known reason why.

v64 an hour ago | parent [-]

Those problems are because of the tobacco. Zyn packets et al are just nicotine, and nicotine itself has not been shown to be a carcinogen.

gwbas1c an hour ago | parent [-]

At this point, I wouldn't assume that any nicotine delivery system is safe.

IE, e-cigarettes used to be promoted as safe, until the popcorn lung incident: https://en.wikipedia.org/wiki/Bronchiolitis_obliterans#E-cig... (TLDR, some e-cigarettes used diacetyl as a flavoring, which is safe to eat but very toxic to inhale.)

(Kinda stinks because nicotine is a cool drug.)

mapt 29 minutes ago | parent [-]

The lipid pneumonia outbreak was a thing exclusively associated with THC vapes, which are an illegal but widespread cottage (garage) industry where one summer, one of the thousands of manufacturer-enthusiasts made a forum post about the innovation of maybe using vitamin E acetate as a thickener. Experiments were performed, positive results were obtained, and products went out to distributors. The hazard to heavy users (perhaps for manufacturers with poor blending practices, we don't know) who showed up in the ER, was recognized within a month or two, and everybody immediately stopped using vitamin E acetate as a thickener. It took most of a year of panic for the last of that summer's merchandise to percolate through the supply chain.

The outbreak was initially hard for users to trace in particular because of how brands worked in that (again, moderately illegal) industry - a "brand" was basically a paper label/bag production line shipped in the clear from a printer, to hundreds of individual manufacturers, who negotiated their own distribution. Conclusions like "Mellow Mallow Blurple is a safe brand, I tested it" ended up being invalid.