Sometimes the symptoms are so ambiguous that it is hard to nail anything down. It’s the same thing with Lymes disease, which is definitely a real thing, but there aren’t good, reliable tests for it. It takes a long time to manifest and the symptoms vary wildly from person to person.

There are increasingly positive markers - autonomic dysfunction in previously healthy people, measurable small fiber neuropathy, and auto immune dysfunction in largely unmapped parts of the immune system.