My understanding (very informal armchair) is that someone could relatively easily wipe out aedes aegypti using a gene drive with a sort of sex-selective infertility:

Release a few thousand females carrying a gene drive that produces all infertile males, and all fertile females (who all also have the same gene due to it being a gene drive). Every generation, there are more and more infertile males, and more and more fertile females carrying this extinction gene. After several generations (a.k.a. a few years), the population collapses completely.

I vote yes.