Yes, there is always going to be someone somewhere that sees some sort of issue. My point wasn’t that nobody anywhere has ever experienced a negative consequence, but that at scale, it is overwhelmingly safe and so it isn’t really worth advising the general public to tailor their dose.

Any of the rare issues that people do experience—especially at the 5g/day level across age and weight—are minor, acute, and easy to resolve by simply lowering the dose.