Estrogen (specifically Estradiol, E2) is one of the most important systemic hormones in both men and women

I've spent a significant amount of my free time for the last 15 years studying androgen physiology and self-experimentation.

Here are a few facts about estradiol that others might find surprising:

1. E2 acts as a master metabolic/energy regulator in humans. ER-alpha and pan-ER agonists are being developed for obesity and metabolic disorders. Example: SLU-PP-332

2. Libido in males is regulated by E2. Androgens like testosterone/DHT seem to be required to support the biology of erectile function, but for mental libido estrogen is the primary component.

3. Estradiol is synergistically anabolic with androgens. This is why cattle hormone implants contain a blend of Trenbolone and E2

Estrogen has so many supporting functions in brain, muscle, adipose tissue, and bone health...

Apologies for no citations and rough formatting but currently on a phone. Happy to provide citations when home

Re #2, in the mtf trans experience high estrogen and low testosterone are correlated with low libido, with some individuals even temporarily stopping antiandrogen medications in order to get some back

Any remedies to reverse this?