I do all my dev inside docker/orbstack environments. I've been using a Tailscale sidecar for each, which has let me easily spin up second (and third!) copy of each repo without having to worry about them interfering with each other (the same open ports etc.). I've not extended to using worktrees, as right now I prefer entirely separate clone's of a repo, but that may well change and I suspect this would work well for that too.

https://robgough.net/multiple-app-instances-with-tailscale

Also has the handy effect of making it super easy to share my dev environment with anyone else on my tailnet, though this could be locked down if needed.