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antinomicus 2 hours ago

Risks? The risks of a colonoscopy are crazy low though.

goosejuice 14 minutes ago | parent | next [-]

The risk is the primary reason the age for first colonoscopy is so high. Even with cologuard it's not typical before 40 unless you have family history.

There's also risks of false positives/negatives for some tests which complicate matters as well.

aprdm an hour ago | parent | prev | next [-]

They are until they aren't. My grandmother had a puncture and almost died

ramesh31 2 hours ago | parent | prev | next [-]

>"Risks? The risks of a colonoscopy are crazy low though."

Not at the statistical level. Death rate from complications is about 1 in 10,000: https://www.endoscopy-campus.com/ec-news/risk-of-death-from-...

panarky 8 minutes ago | parent [-]

The risk of serious complications like major bleeding or perforation is closer to 40-80 per 10,000, significantly higher than the roughly 3-5 per 10,000 annual chance of actually having colorectal cancer for low-risk groups.

My doctor says that since Cologuard catches a large percentage of those 3-5 per 10,000 without any of the colonoscopy risk, the marginal benefits from colonoscopy really aren't justified since FIT+DNA testing is almost as good, at least for low-risk cohorts.

Very few things in medicine are zero risk. I wish more doctors would help balance the risk of doing A vs. the risk of doing B vs. the risk of doing nothing.

It's all Bayesian conditional probabilities, considering your own individual risk factors, and considering the false positive rate and false negative rate of each test.

2 hours ago | parent | prev | next [-]
[deleted]
amanaplanacanal 2 hours ago | parent | prev | next [-]

There is still the rush of perferating the colon, but I assume it doesn't happen very often. Cologuard has got to be cheaper though.

NotGMan an hour ago | parent | prev [-]

2 to 3 colonoscopies per ~1k to 2k people cause severe rupture of the intestines that require urgent surgery.