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robobro 4 hours ago

Saliva divinorum is inherently dysphoric due to its agonism of the kappa opiod receptor. For a different cheap legal drug that affects serotonin and the NMDA receptors like ibogaine does, there's always off label use of dextromethorphan (cough medicine)!

panflute an hour ago | parent | next [-]

Again I'm a bit baffled as to what the unstated thought process is. Ibogain and Saliva divinorum share a short term dysphoric experience from kappa opioid receptor interference that might be an effective way to eliminate Trauma from earlier memories. Why use the more dangerous of the two and why avoid the experience if the experience is the intervention?

tastyfreeze 3 hours ago | parent | prev | next [-]

Really difficult to find a cough syrup with only high amounts of DXM and nothing else. All the brands changed their recipes in the late 90s.

Trasmatta 4 hours ago | parent | prev [-]

DXM is also the active ingredient in the antidepressant Auvelity (combined with bupropion)

Lot of interesting studies and anecdotes on its efficacy as an antidepressant