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Aurornis 3 hours ago

I think this is the clinical trial registration: https://clinicaltrials.gov/study/NCT03408886?tab=results

It is marked as having results submitted but quality review has not been completed.

N=60 and a placebo group, which is better than the N=18 and no placebo group of the first study.

There have been so many small scale trials showing amazing autism improvements that failed to replicate in larger, better controlled trials. I wouldn’t get excited yet.

The typical pattern is to show unbelievably good results in the first open-label trial with a small number of patients (their n=18 trial that claims to have cured severe autism in many children), squeak by with some marginal improvement in the next trial over placebo, then the third trial becomes a game of trying to keep the study small enough that they can hope to p-hack a result that the FDA might accept.

cpncrunch 2 hours ago | parent [-]

Study completed in 2022, but still no results posted or study published.

Sverigevader 38 minutes ago | parent [-]

I've never really thought about this but, could it be because they don't want people to "try this at home"? Either because of safety issues, or my actual hypothesis, because they want to keep their possible pool of candidates as big as possible?