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rincebrain 4 hours ago

From my understanding, the problem is volume.

You want to land a substantial amount of, ahem, shit in there, since don't just want it to colonize one portion of the gut, and it's got quite a lot of competition.

So you would be talking a truly astonishing number of pills, I think, to compare to the volume you can manage with a tube.

WP suggests that it's about 100g (or 100000mg) of actual feces then mixed in a larger volume of saline or milk, and you'd probably need to have additional volume for assumed losses and whatever coating you think would work.

That is a _huge_ amount to put in pills.

throw310822 4 hours ago | parent [-]

Good point, but shit seems to be made of a lot of stuff- ~75% water, undigested food and fiber, fats, inorganic matter... Bacteria seem to be about ~30% of the dry weight. So of those 100 grams, you'd get maybe 7/8 grams of bacteria? If so, these could possibly be delivered by a number of small capsules taken in the course of several days.