CRISPR has not been a thing for decades. Biotechnology is advancing and AI is lowering the bar to use it. In 2018 a PhD student was able to synthesize an infectious horsepox virus: https://journals.plos.org/plosone/article?id=10.1371/journal...

So far the overlap between people with bioengineering capabilities and murderous tendencies has been very low. As the technology becomes available to more people that overlap may increase. Even if it never comes within reach of one person, what about North Korea, or Iran?

AI can be jailbroken. The LLM safeguards your argument relies on were put in place by the people you're criticizing for being too safety-conscious. Security through obscurity is no guarantee.