Unfortunately, all the native "system" GUI frameworks are all terrible in their own unique ways.

Unless you mean drawing the gui directly to a graphics surface, which often results in even poor accessibility and system integration unless the developer cares a lot about that and puts a lot of effort into it.

Qt is used to develop arguably the best desktop environment on the market - KDE Plasma - as well as a miriad of serious software artifacts. It's not exactly native to MacOS and Windows, but advantages overweight the downsides.