So we do know that all the tiny interactions like charge of particles etc must work side by side with all the big interactions like gravity as otherwise how would anything as we know it work. However it could as easily be neither are the right way to interpret the world and there is something we are missing, or we are right and we can find a method to combine the theory of the big and the small interactions but we are missing a section. At the end of the day we can't interact in any meaningful way with more than half the matter in the universe (it's proven to exist due to a gravitational pull), so it's clear we can't experience a lot of the universe and we definitely can't explain a lot.

So yes there is a solution, but do we, as humans, have the ability to come up with it, who knows. I would say it's unlikely.