They have limitations, specially when driven to the limits of the specifications.

When doing 4k@120fps 4:4:4 chroma you might have to deal with longer handshakes and sometimes even no handshake at all. Or random dropouts. Or HDR not activating properly.

I thought handshakes were just when you were setting up a connection no?

Random dropouts tho sound bad… with high speed signaling also sounds like a pain to figure out