Assuming you are thinking about software architecture and looking under the hood, you are likely to be reading much more code than before. Python is really nice on the eyes and you can easily get a good grasp of what the code is doing. Plus, it's dynamically but strongly typed, so what you see in the code is usually what you get.

I think the rule of thumb is to use the tool that is right for the job and that you are going to be able to understand the output.