The upcoming Prusa support for INDX (by Bondtech) is going to be interesting, especially for business use cases where waste is a primary concern.

https://www.prusa3d.com/product/indx-conversion-kit-8-toolhe...

The main thing keeping me from making the multi-material jump is the waste. I have a couple Vorons and would love to be able to print with different materials at the same time, but the waste with the current solutions is so egregious.