Using a proper NIC (Chelsio) with their iSCSI accelerator will boost your iSCSI performance significantly. Another alternative is Mellanox with RDMA. You need CX4+ for optimal performance over TCP/IP, while the cheap CX3 is excellent with IPoIB. If you have a lot of packet drops and retransmissions, another option for boosting iSCSI performance is getting a network switch with a lot of memory for packet buffering. This helps with incast congestion. There are special switches with gigabytes of memory built for this.

NVMe-oF is the best protocol with least overhead for network drives, with a proper setup you lose only 10-20% latency compared to local disk even with Intel Optane. Throughput should be almost similar.