There are a lot of assumptions in those laws, and they were exploited by Asimov himself in his short stories and books. Redefining what is human, adding a zeroth law, weakening laws, lack of understanding of human nature (i.e. lending an arm to a dangerously angry woman), even with those theoretically perfect laws it was still able to be exploited and cause harm.

Even the Men on Fire episode of Black Mirror was able to trick humans, with laws or not.