My main card game lately has been the Legendary system of games, in particular the Marvel version (although I did just order the James Bond version this morning too after playing the app version this past week). I like to play it with two players and alternate hands, but you can play it solo too.

Another one I like to play is Ashes, which has solo enemies you can play against. It's entry point nowadays is called Ashes Ascendancy.

And I play a lot of cooperative card games by the publisher Fantasy Flight Games, namely Marvel Champions, Lord of the Rings - The Card Game, and Arkham Horror - The Card Game. Lord of the Rings is starting to go out of print, and the older content for the other two is out of print, but the other two are still coming out with new content (and I have all the old stuff so I can still play them).

All of these have a ton of content with them, so I can play a bunch of games and not get bored of them. I've played each of them over 50 times, and some as many as 150 times, and yet there's still plenty I haven't played for each of them.