I've been using ETP plus adblock-rs in Waterfox for 2 weeks. I don't see much a difference compared to ETP + ublock origin apart from some cosmetic filtering. The fact that it's not an extension supposedly allows to block at more layers so it's theoretically better than an extension (https://github.com/BrowserWorks/waterfox/issues/4182)

Note that there are (were?) also some small bugs in the waterfox integration (such as the configuration options sometimes disappearing).