I haven't heard about it, but the combo would have a synergistic effect as they both address different coagulation pathways. I take them together for other reasons - I take vitamin K (K1, and K2 in MK-4 and K2 MK-7 forms) to direct calcium to the bones, not to the tissues, and, of course, anticollagulation. For the latter, I also take Nattokinase, but the main reason I take Aspirin is its protection against cancer.