> Thalidomide never even made it to use in the USA.

What? It was initially blocked by the FDA, but was later approved for use in cancer, where it is in fact a front line drug for some myelomas, albeit with significant usage warnings.

It was never approved in the US for the on-label use for which it gained its reputation (it's a potent teratogen and was prescribed --- never officially in the US --- for morning sickness).

Fair, I was talking more the initial pregnancy use, but even still that further pushes my point that those examples have either never been considered perfectly safe, or have been in active normal usage for so many years that you really have to squint to say it's unsafe.