I think the fears about glyphosate resistance owes too much to antibiotic resistance, but I am not really sure it makes sense.

I suppose there's some regimen where you carefully monitor every plant sprayed with a weedkiller is monitored for survival and killed with fire if it survives, or some other extreme measure to be sure there are no survivors to develop resistance, but realistically the weeds are going to develop resistances over time.

And ... so what? The value of a weedkiller like glyphosate is using it to kill a lot of weeds in wide-scale agriculture. If the weeds develop a resistance to it, and we stop using it because it's no longer effective, we're not really in a worse position than if we never used it at all. It's not like there are some really bad weeds we need to save it to be able to combat.