From personal experience (sorry, n=1), I can eat pure Aspartame powder and have zero reaction - no increase in glucose, no "anticipatory" response - nothing.

When I have other sweeteners such as taking a swig of a stevia-laden diet iced tea, I have a reaction. I used to be able to drink the exact same iced tea when they used Aspartame with no effect. I don't think your body is "fooled" by sweet tastes - it only reacts when there is actually something to process.

The fact sucralose is being added into all kinds of products has removed many choices for me, which is unfortunate as the selection was quite small to begin with.