Strix Halo, to my knowledge, does not support PCIe 5.0 NVMe drives, unfortunately, despite it being Zen 5, and Zen 5 supporting the PCIe 5.0 standard.

While many other NUCs may support them, what most of them lack compared to Strix Halo is a 128 GB pool of unified LPDDR5x-8000 on a 256 bit bus and the Radeon 8060S iGPU with 40 CU of RDNA 3.5, which is roughly equivalent in processing power to a laptop 4060 or desktop 3060.

The Radeon 780M and Radeon 890M integrated graphics that come on most AMD NUCs don't hold a candle to Strix Halo's 8060S, and what little you'd gain in this narrow use case with PCIe gen 5, you'd lose a lot in the more common use cases of models that can fit into a 128 GB pool of unified memory, and there are some really nice ones.

Also, the speeds you're suggesting seem rather optimistic. Gen 5 drives, as I understand, hit peak speeds of about 28-30 GB/s (with two in RAID0, at 14-15 GB/s each), but that's peak sequential reads, which is neither reflective of sustained reads, nor the random read workloads that dominate reading model weights.

Maybe there are some Intel NUCs that compete in this space that I'm less up to speed with which do support PCIe 5. I know Panther Lake costs about as much to manufacture as Strix Halo, and while it's much more power efficient and achieves a lot more compute per Xe3 graphics core than Strix Halo achieves per RDNA 3.5 CU, they Panther Lake that's actually shipping ships with so many fewer Xe3 cores that it's still a weaker system overall.

Maybe DGX Spark supports PCIe 5.0, I don't own one and am admittedly not as familiar with that platform either, though it's worth mentioning that the price gap between Strix Halo and DGX Spark at launch ($2000 vs $4000) has closed a bit (many Strix Halo run $3000 now, vs $4700 for DGX Spark, and I think some non-Nvidia GB10 systems are a bit cheaper still)