I especially love issues automatically "closed due to inactivity" just to keep the number of issues down :V

Sometimes people open issues without proper information. It cant be replicated and nobody else is jumping in that it affects them. You may suspect its something else, maybe with their environment, but if they don't engage what else can you do? Tell them you are closing it and specify what kind of info you need if they ever get around to providing it and it can be reopened.