| ▲ | hilbert42 2 days ago | ||||||||||||||||
Where's the authority on that? Ethanol can be used as a temporary measure in methanol poisoning as it temporarily outcompetes methanol in the metabolic process. So it's only useful until proper medical help arrives when better alternatives such as fomepizole are administered. Even then there is no guarantee of success. Methanol is still metabolized to dangerous formaldehyde and formic acid by the liver's alcohol dehydrogenase. The logic of giving ethanol or fomepizole is to slow down the rate of production methanol's dangerous metabolic byproducts so less damage is done, nevertheless those dangerous metabolites are still produced. Ethanol's first-pass metabolite is acetaldehyde and it is still toxic but not to the same degree as those of methanol. It is incorrect to say ethanol is an antidote for methanol poisoning. Using ethanol is a last-ditch stand to try and take some minor control of an otherwise out of control situation. There's nothing subtle about it—it's a blunderbuss approach that often doesn't work well because replacing one poison with a less toxic one is a pretty hit-and-miss process. Antidotes counteract poisons, that's not what happens when you give ethanol in methanol poisonings. | |||||||||||||||||
| ▲ | dnnddidiej 2 days ago | parent | next [-] | ||||||||||||||||
It is technically an antidote though. Based on the definition of antidote. | |||||||||||||||||
| ▲ | btreecat a day ago | parent | prev | next [-] | ||||||||||||||||
Where are the sources on your claims that ethenol is only a temporary or last ditch treatment? | |||||||||||||||||
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| ▲ | pessimizer 21 hours ago | parent | prev [-] | ||||||||||||||||
> The logic of giving ethanol or fomepizole is to slow down the rate of production methanol's dangerous metabolic byproducts so less damage is done, nevertheless those dangerous metabolites are still produced. Who cares if dangerous metabolites are "still produced" when the danger has been limited? It's like claiming that blood transfusions don't help with shock because the patient still lost the same amount of blood. > Using ethanol is a last-ditch stand to try and take some minor control of an otherwise out of control situation. This is some weird-ass over-elaborate synonym for antidote. > There's nothing subtle about it—it's a blunderbuss approach that often doesn't work well because replacing one poison with a less toxic one is a pretty hit-and-miss process. I don't even know what this is supposed to mean. This all reads like AI slop. > Antidotes counteract poisons, that's not what happens when you give ethanol in methanol poisonings. You literally give it to them to counteract the poison. You're using a idiosyncratic version of the word "counteract," which doesn't relate to the health or survival of the person poisoned, but has a lot to do with the absolute levels of "dangerous metabolites produced." | |||||||||||||||||
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