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arjie 3 hours ago

I used retatrutide for weight loss and went from 199.3 lbs to just under 175 lbs. I kept daily notes through the process. Here's a quick AI one-paragraph summary if you're curious: https://pastebin.com/XACNYKvs

Overall I'm quite pleased with the effects and many of the properties of this treatment that people dislike are actually properties I was looking for. Essentially, for pharmacological interventions I want impermanent effects with a clear dose-response relationship and ideally minimal or no adaptation.

So the fact that people gain weight when they go off it and then lose weight again when they go on it was good. That meant it's fairly easily undoable. The fact that the more you take the more you lose also was pretty good to know though for the majority of the time I took less than any tested dose (and the effects were quite strong on those).

I did experience quite a bit of adaptation so I needed to up the dose until I was in the range tested by the end. I've been off it for a month now and been pretty much flat, but we've been traveling since I stopped and so a lot has changed (no more lifting, lots more eating, lots more walking).

Rough cost for the retatrutide is $1.25/mg.

staticassertion 2 hours ago | parent | next [-]

Was cost the reason you went for it over tirzepitide? I feel like retatrutide is still way too early to mess with, it's giving me real "vioxx" vibes of messing with too much at once.

arjie 2 hours ago | parent [-]

No, I had access to free tirzepatide. I chose retatrutide because early results seemed promising and safe and since I was going to run a short-term self-trial I wanted the most effective peptide.

staticassertion 2 hours ago | parent [-]

Hey, fair enough! To each their own.

EiZei 3 hours ago | parent | prev [-]

> Rough cost for the retatrutide is $1.25/mg.

Even with free healthcare that seems like a foolish place to save money when very widely used alternatives exist in the regulated market.