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shevy-java 6 hours ago

> For a chemist, “peptide” has a pretty clear definition: any relatively short chain of amino acids, and when they get longer we go ahead and call them “proteins”, although the dividing line is a matter of personal opinion.

So, it is not just chemist but molecular biologist too. And the above is also not entirely correct. Yes, the author refers to size as threshold, before something is called a "protein". But the term protein has additional meanings that a peptide does not automatically have. For instance, a protein typically has a specific 3D conformation. It may be "sticky" after degradation or unfolding, but for the most part a protein is something with a 3D structure. A peptide does not necessarily imply the same. A protein may also have several polypeptide chains - insulin is a simple example for that: https://en.wikipedia.org/wiki/Insulin#Structure (A and B chain)

> So the number of different possible peptides is just ridiculously huge.

That's no surprise either - that's due to the code used. You add to the code, so of course length plays a role, as does the variety. There is a DNA->aminoacid mapping. The first has four possibilities per slot; the latter 20 (or more if you include e. g. selenocystein or pyrrolysine; and you have various post-translational modifications too, so you have more variety per slot).

> For comparison, it has been about ten trillion seconds since Homo sapiens emerged as a separate species.

The whole species concept is IMO outdated. It was created before people knew that DNA codes for the complexity in pretty much any species (excluding RNA viruses but they have reverse transcriptase, at the least some viruses, so ultimately RNA->DNA).

> The other one (by Sarah Hood) relates all this to RFJ Jr.’s advocacy. The flip side of “the government shouldn’t be able to force me to vaccinate my kids” is “I should have the right to take whatever medicines I want to without the government getting in my way”.

I don't see why that would be questionable. Would people do as Trump tells them to do? I would not. If you see Trump as a lobbyist, how many private interests may his government have? If they have a commercial interest then their statements may be biased.

> You don’t have an LC/MS or an NMR machine in your garage, so you can’t be sure what it is you’re really injecting

Right, so the whole system depends on trust. This is already a problem because you have to trust not only the government but ALL who were involved in scientific publishing. There were lies told in science too: https://en.wikipedia.org/wiki/Retraction_in_academic_publish...