If only there were a federal administration whose responsibility it was to collect data about food and drugs so we could rely on something more than anecdotes from random strangers on the Internet.

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JumpCrisscross 7 hours ago | parent [-]

Do you have a link to those data showing GLP-1 agonists are ineffective?

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rzmmm 6 hours ago | parent [-]

I emphasize it's like the drug disulfiram: Very effective as long as patients take the full dose, but the lack of real-world efficacy stems from the difficulty in adhering to the treatment.

This study found that 84.4% non-diabetic patients stop taking GLP-1 drugs within two years. https://jamanetwork.com/journals/jamanetworkopen/fullarticle...

	▲	JumpCrisscross 4 hours ago \| parent [-]
		> the lack of real-world efficacy stems from the difficulty in adhering to the treatment Do you have a source for this "lack of real-world efficacy"? > This study found that 84.4% non-diabetic patients stop taking GLP-1 drugs within two years "With a with a median on-treatment weight change of −2.9%" [1]. Of those who discontinued and experienced "weight gain since discontinuation," they were "associated with an increased likelihood of GLP-1 RA reinitiation." I'm genuinely struggling to see how this source shows real world inefficacy. In my friends, all of them stopped taking GLP-1 drugs within 2 years because all of them lost the weight they wanted to. Out of curiosity, what sources lead you to believe this? > it's like the drug disulfiram Have clinicians made this connection? [1] https://jamanetwork.com/journals/jamanetworkopen/fullarticle...