>our biological and environmental reality is substantially different.

As true as it might be, that does not mean that it is possible to work around evolution to change ourselves to fit better with the new reality.

Not the OP, but evolution will often select for less energy expenditure as most animals are calorie constrained or at least during certain times of the year (c.f. animals that hibernate to survive low calorie availability).

It seems plausible to me that the immune system might be calorie intensive to be on full alert all the time. However, I suspect that having the immune system be more active will likely lead to other complications such as autoimmune disorders or even something as common as hayfever.

We know enough specific things about immunology and about the illnesses we're trying to avoid to be something more than clueless and we're learning more all the time, including about the potential applications of "everything vaccines" that are being tested for potential programmatic use.

There's no wise guiding force behind evolution. It's all guesswork.

I would say you are both right in that if you have two competing variables (on-time for the defence vs calorie consumption), when the main causes of death before procreating were infectious disease and malnutrition before modern times, I would expect some equilibrium to be reached and we have not had that much time to evolve since caloric scarcity in the western world was a solved problem for large swaths of the population.

If in the future we could trade a few hundred extra calories per day for a great immune system (without auto-immune side effects) we would have found a nice cheat code!

Thinking about your point- I bet we do not know if some people have it on or not. It feels like something that would have to be specifically investigated.

Whilst I agree that there's a lot of people with D3 deficiency (at least during winter), it's also worth being careful of taking too much D3. Typical signs of too much D/D3 are nausea, loss of appetite, more frequent urination, thirst, weakness, confusion or brain fog.

It's worth being aware of that as the recommended limits for vitamin D are laughably too small, so it's common for people to take much larger amounts. I believe that 4k IU is considered a safe adult dosage.

Same here in France, and it’s free as in “paid by public money".

persons aged 65 years and over; people under 65 with certain chronic diseases (including children from 6 months of age); pregnant women; people with obesity (with a body mass index, BMI, greater than or equal to 40); persons staying in a follow-up care facility or in a medico-social accommodation facility, irrespective of their age. Vaccination is also recommended for other populations, in order to ensure indirect protection: health professionals (especially those who have contact with people at risk), the entourage of infants under 6 months at risk of serious complications and immunocompromised people, home help for vulnerable people, professionals exposed to swine and avian influenza viruses.

https://www.service-public.gouv.fr/particuliers/actualites/A...

If someone got the jabs and has long COVID now, it'd be best to assume that it's not long COVID but vaccine injury, unless we acknowledge that the vaccines aren't all that effective (nor safe for that matter). At least the few people around me willing to consider this got this confirmed by their doctors after many tests and lots of gaslighting.

That's true.