According to the EFF fingerprinting website, Firefox + uBlock Origin didn't really make my browser particularly unique.

But turning on privacy.resistfingerprinting in about:config (or was it fingerprintingProtection?) would break things randomly (like 3D maps on google for me. maybe it's related to canvas API stuff?) and made it hard to remember why things weren't working.

Not really sure how to strike a balance of broad convenience vs effectiveness these days. Every additional hoop is more attrition.