Dioxus originally was more like ReactJS and used hooks. However, they have since migrated to using signals as well which makes Dioxus and Sycamore much more similar.

One remaining major difference is that Dioxus uses a VDOM (Virtual DOM) as an intermediary layer. This has a few advantages such as more flexible rendering backends (they also support native rendering for desktop apps), at the cost of an extra layer of indirection.

Creating native GUI apps should also be possible in Sycamore, and something I'm interested in although there is currently no official support. However, I think one of the big differences with Dioxus would be that Dioxus supports "one codebase, many platforms" whereas I think that is a non-goal with Sycamore. Web apps should have one codebase, native apps should have another. Of course, it would still be possible to share business logic but the actual UI code will be separate.

How does it compare to leptos? Leptos is roughly based on Solidjs and uses signals, to enable fine grained reactivity and avoid a vdom. Why sicamore over leptos?