I'm really glad to hear its going well for you! Her neurologist told us the achievable goal was to stop progression entirely. We were both surprised to hear that. She chose Tysabri because her brother has also had great results with it, and also because it mostly acts to keep your immune system outside the blood-brain barrier, rather than to target specific types of immune cells. Our understanding is you can basically stay on this until it stops being effective or you test positive for JCV exposure, at which point it's on to Ocrevus most likely.