Safety culture requires the ability to learn from mistakes, the capability to ground planes (without that turning into a political problem), and someone to foot the bill. (Which did not always happen, Boeing MCAS with a SPoF AoA sensor without retraining. A chain of cost-cutting decisions. And of course there were usual problems with market distorting subsidies to both Boeing and Airbus.)

NASA's missions are way too big, because the science payloads are unique, so they "can't do" launch early, launch often. And then things sit in storage for years, waiting for budget. (And manned flights are in an even worse situation of course, because they are two-way.)

And there's too much sequential dependency in the marquee projects (without enough slack to be able to absorb problems if some earlier dependent outcome is unfavorable), or in other words because of time and cost constraints the projects did not include enough proper development, testing, verification.

NASA is doing too many things, and too much of it is politics. It should be more like a grant organization, rewarding cost-efficient scientific (and engineering) progress, in a specific broad area ("spaaace!"), like the NIH (but hopefully not like the NIH).

> without enough slack to be able to absorb problems if some earlier dependent outcome is unfavorable

It's strange because unmanned mission are heavy in the "under promise and over deliver" territory. They may say something like "we are sending a car to Mars for a month", but everything is over engineered to last for a year. Then it miraculously work for eleven month and it's a huge success.