I suspect we will see something similar to CRAM that is a little less aggressive for these drones. CRAM uses a huge stream of rounds because it has to target supersonic munitions. But a drone doing 200-300 knots could be taken out with a proxy fused shell shot from a computerized turret on a HMMWV.

In addition you will probably start seeing FIM-92k missiles (Stinger) on loyal wingman style Predator, Reaper and Viper drones using link 16 guidance from F-35 and E-3. There has already been an air to air kill with the Reaper.

https://www.popularmechanics.com/military/aviation/a23320374...