Hepatitis C has effectively been cured. Obesity, sickle cell, and cystic fibrosis have all heard their death knell though not a complete cure.

Hep C regimens are getting closer and closer to "take a pill for a couple months" - no more interferon injections or multiple rounds of multiple drugs.

Trikafta is a functional cure for 90% of CF patients, I believe - not easy or cheap but normalizes what you care about bar the administration of the treatment itself.

Sickle cell has CRISPR treatments that are incredibly invasive and awful but do functionally cure the disease more or less permanently for a cool "couple million"

And everyone knows about GLP-1 drugs for obesity. The latest batch are as good or better than bariatric surgery without, you know, the surgery part.

Great list!

There's also Leber congenital amaurosis, a form of blindness that now has a (very expensive) gene therapy: https://www.wgbh.org/news/2017-10-12/fda-panel-endorses-gene...