Sounds like the start of research ending in antimatter bombs.

Unless we'd be fighting literal alines in space, and need a weapon for them, I think this would be many many many orders of magnitude too expensive / tricky for earth use. We have plenty of non sci-fi big boom sticks already as it is...

The energy used in creating and containing this antimatter was many orders of magnitude greater than it would release on collision with matter.

The most expensive bomb ever.