Much of the original motivation for async was for single threaded event loops. Node and Python, for example. In C# it was partly motivated by the way Windows handles a "UI thread": if you're using the native Windows controls, you can only do so from one thread. There's quite a bit of machinery in there (ConfigureAwait) to control whether your async routine is run on the UI thread or on a different worker pool thread.

In a Unity context, the engine provides the main loop and the developer is writing behaviors for game entities.