We recently switched to pnpm, in part to guard against supply chain attacks (https://pnpm.io/supply-chain-security).

Reading this got me wondering whether uv has something similar, and indeed it does appear to (https://docs.astral.sh/uv/reference/settings/#exclude-newer)

Wherever practical, I also recommend using devcontainers, so that in addition to breaking supply chain security, large-scale damage would require an unpatched sandbox exploit too.