Kind of makes sense that stopping taking a drug that reduces heart attack and stroke risk leads to a return to the higher risk of before.

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ErroneousBosh 4 hours ago | parent [-]

It doesn't reduce heart attack and stroke. It reduces appetite, kind of, and gives you a sore stomach while making you shit yourself inside out. All this can, with care, help contribute to weight loss.

Weight loss can reduce heart attack and stroke, but GLP-1 does not.

You could also reduce heart attack and stroke risks by not eating crap and going for a walk every so often.

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cthalupa 3 hours ago | parent | next [-]

We see risk reduction for heart attack and stroke for people on GLP-1s even without weight loss, which belies the idea that the protection only comes from losing weight.

Edit: In fact, from the study -

BMI went from 35.86 (Continued) to 34.57 (Discontinued) to 35.48 (Interrupted),

Heart failure percentage was 11.57% for continued use, 12.73% for discontinued, 11.92% for interrupted

NICM went 3.10% for continued, 3.36% for discontinued, 3.31% for interrupted

BMI was higher for the continuing users and they still had lower heart failure and NICM rates than the discontinued and interrupted groups. (Also a bunch of other things including stroke and heart attack but I didn't want to write all of these out)

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shlant 16 minutes ago | parent | prev | next [-]

> You could also reduce heart attack and stroke risks by not eating crap and going for a walk every so often.

Oh wow it's so simple! why has nobody thought of this before??

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rootusrootus 2 hours ago | parent | prev | next [-]

What is it about GLP1s that bring out the kooks who suddenly think diet and exercise are the only valid medical treatment? Is it a moral issue?

	▲	cthalupa 2 hours ago \| parent [-]
		As best as I can tell, people are very attached to having achieved their body weight through whatever means they have determined are valid and derive self value from it, and believe that GLP-1s are cheating to achieve a result they worked harder for.

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malfist 3 hours ago | parent | prev [-]

Your comment is all kinds of wrong.

A) it does have cardio protective effects.

It does reduce your appetite, and for most people have very few side effects. If you get nausea you're titrating up too fast. Most people, because it slows gastric emptying, it doesn't make them shit themselves "inside and out". GLP1s are a decent option for treating ibs-d or bile acid issues and is better tolerated than your bile acid sequesterants.

> You could also reduce heart attack and stroke risks by not eating crap and going for a walk every so often.

This victim blaming advice has been given for decades and obesity rates have been climbing for decades. Only glp-1s have reduced that.