These days, I assume every web page is actively hostile until proven otherwise. Use as many layers of protection (uBlock, PiHole, various other extensions, etc.) as possible, filter out content when possible, and bail if those don't work.

Youtube is just about the worst that I've put up with for it. Every single second it's trying desperately to inject more ads, which the blocker swiftly removes. After watching for a few minutes the block count can be in the several hundred...